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The FDA has been testing medications for NDMA since 2018, when drug-makers in India and China were forced to issue numerous recalls for several blood-pressure drugs that were contaminated by NDMA.
In September 2019, the FDA issued a warning after Zantac® heartburn medications and generics tested positive for NDMA (N-nitrosodimethylamine).
In April 2020, the FDA pulled all remaining Zantac and ranitidine off store shelves in the U.S. due to the risk of cancer. The agency determined that levels of a cancer-causing chemical impurity (NDMA) can increase in the pills over time, or when the pills are stored above room-temperature. This means all over-the-counter and prescription-strength Zantac and ranitidine will no longer be sold in the U.S.